Portuguese Water Dog For Sale Florida 


Portuguese Water Dog For Sale Florida

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GM1 Storage Disease, one of a family of conditions called GM1 gangliosidoses, is a recessive, genetic disorder that is inevitably fatal. It is caused by ... Read more a deficiency of beta-galactosidase, with resulting abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells. Because PWDs are all rather closely related to one another and share a limited gene pool, PWDs who were GM1 Storage Disease carriers were able to be genetically identified, and the condition has now been almost entirely eliminated from the breed. All breeding stock should be tested for GM-1 storage disease or GM1 gangliosidoses, which is a fatal nerve disease that typically appears when a puppy is approximately six months of age. The affected puppy will show clinical signs of cerebellar dysfunction including ataxia, tremors, paresis, and seizures. The pet may also exhibit a change in temperament. Lesions of the retina and clouding of the cornea may occur. GM-1 storage disease is a recessive deficiency of betagalactosidase. The condition has been genetically identified and is no longer common.

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